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|000001f0| 00 00 24 55 6e 69 71 75 | 65 5f 49 44 7b 59 52 42 |..$Uniqu|e_ID{YRB|
|00000200| 30 38 37 33 35 7d 0d 0a | 24 54 69 74 6c 65 7b 54 |08735}..|$Title{T|
|00000210| 72 65 61 74 6d 65 6e 74 | 20 6f 66 20 41 64 76 61 |reatment| of Adva|
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|00000260| 74 68 6f 72 7b 0d 0a 4c | 69 70 70 6d 61 6e 2c 20 |thor{..L|ippman, |
|00000270| 53 4d 0d 0a 4d 65 79 73 | 6b 65 6e 73 2c 20 46 4c |SM..Meys|kens, FL|
|00000280| 20 4a 72 7d 0d 0a 24 41 | 66 66 69 6c 69 61 74 69 | Jr}..$A|ffiliati|
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|000002f0| 7d 0d 0a 24 4a 6f 75 72 | 6e 61 6c 7b 41 6e 6e 20 |}..$Jour|nal{Ann |
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|00000310| 6c 75 6d 65 7b 31 30 37 | 7d 0d 0a 24 50 61 67 65 |lume{107|}..$Page|
|00000320| 7b 34 39 39 2d 35 30 31 | 7d 0d 0a 24 44 61 74 65 |{499-501|}..$Date|
|00000330| 7b 4f 63 74 6f 62 65 72 | 20 31 39 38 37 7d 0d 0a |{October| 1987}..|
|00000340| 24 59 42 56 6f 6c 7b 31 | 39 38 39 20 59 65 61 72 |$YBVol{1|989 Year|
|00000350| 20 42 6f 6f 6b 20 6f 66 | 20 50 6c 61 73 74 69 63 | Book of| Plastic|
|00000360| 2c 20 52 65 63 6f 6e 73 | 74 72 75 63 74 69 76 65 |, Recons|tructive|
|00000370| 2c 20 61 6e 64 20 41 65 | 73 74 68 65 74 69 63 20 |, and Ae|sthetic |
|00000380| 53 75 72 67 65 72 79 7d | 0d 0a 24 43 68 61 70 74 |Surgery}|..$Chapt|
|00000390| 65 72 7b 32 2d 39 7d 0d | 0a 24 59 42 45 64 69 74 |er{2-9}.|.$YBEdit|
|000003a0| 6f 72 7b 44 72 73 2e 20 | 4d 69 6c 6c 65 72 2c 20 |or{Drs. |Miller, |
|000003b0| 42 65 6e 6e 65 74 74 2c | 20 48 61 79 6e 65 73 2c |Bennett,| Haynes,|
|000003c0| 20 48 6f 65 68 6e 2c 20 | 4d 63 4b 69 6e 6e 65 79 | Hoehn, |McKinney|
|000003d0| 2c 20 61 6e 64 20 57 68 | 69 74 61 6b 65 72 7d 0d |, and Wh|itaker}.|
|000003e0| 0a 24 54 61 62 6c 65 7b | 54 61 62 6c 65 20 4f 6d |.$Table{|Table Om|
|000003f0| 69 74 74 65 64 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |itted}..|$Comment|
|00000400| 61 74 6f 72 7b 53 2e 48 | 2e 20 4d 69 6c 6c 65 72 |ator{S.H|. Miller|
|00000410| 2c 20 4d 2e 44 7d 0d 0a | 0d 0a 43 6f 70 79 72 69 |, M.D}..|..Copyri|
|00000420| 67 68 74 20 28 63 29 20 | 59 65 61 72 20 42 6f 6f |ght (c) |Year Boo|
|00000430| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|00000440| 68 65 72 73 2c 20 49 6e | 63 2e 2c 20 31 39 38 39 |hers, In|c., 1989|
|00000450| 0d 0a 0d 0a 31 39 38 39 | 20 59 65 61 72 20 42 6f |....1989| Year Bo|
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|00000470| 65 63 6f 6e 73 74 72 75 | 63 74 69 76 65 2c 20 61 |econstru|ctive, a|
|00000480| 6e 64 20 41 65 73 74 68 | 65 74 69 63 20 53 75 72 |nd Aesth|etic Sur|
|00000490| 67 65 72 79 20 28 52 29 | 0d 0a 0d 0a 43 68 61 70 |gery (R)|....Chap|
|000004a0| 74 65 72 20 32 2d 2d 4e | 65 6f 70 6c 61 73 74 69 |ter 2--N|eoplasti|
|000004b0| 63 2c 20 49 6e 66 6c 61 | 6d 6d 61 74 6f 72 79 2c |c, Infla|mmatory,|
|000004c0| 20 61 6e 64 20 44 65 67 | 65 6e 65 72 61 74 69 76 | and Deg|enerativ|
|000004d0| 65 20 44 69 73 65 61 73 | 65 73 0d 0a 0d 0a 4d 61 |e Diseas|es....Ma|
|000004e0| 6c 69 67 6e 61 6e 74 0d | 0a 0d 0a 2d 2d 2d 2d 2d |lignant.|...-----|
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|00000520| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000530| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 54 72 65 |--------|---..Tre|
|00000540| 61 74 6d 65 6e 74 20 6f | 66 20 41 64 76 61 6e 63 |atment o|f Advanc|
|00000550| 65 64 20 53 71 75 61 6d | 6f 75 73 20 43 65 6c 6c |ed Squam|ous Cell|
|00000560| 20 43 61 72 63 69 6e 6f | 6d 61 20 6f 66 20 74 68 | Carcino|ma of th|
|00000570| 65 20 53 6b 69 6e 20 57 | 69 74 68 20 49 73 6f 74 |e Skin W|ith Isot|
|00000580| 72 65 74 69 6e 6f 69 6e | 0d 0a 0d 0a 4c 69 70 70 |retinoin|....Lipp|
|00000590| 6d 61 6e 20 53 4d 2c 20 | 4d 65 79 73 6b 65 6e 73 |man SM, |Meyskens|
|000005a0| 20 46 4c 20 4a 72 0d 0a | 28 55 6e 69 76 20 6f 66 | FL Jr..|(Univ of|
|000005b0| 20 41 72 69 7a 6f 6e 61 | 29 0d 0a 41 6e 6e 20 49 | Arizona|)..Ann I|
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|000005d0| 39 2d 35 30 31 2c 20 4f | 63 74 6f 62 65 72 20 31 |9-501, O|ctober 1|
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|00002070| 74 2c 20 47 61 6c 76 65 | 73 74 6f 6e 2c 20 54 65 |t, Galve|ston, Te|
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|000020f0| 20 62 75 72 6e 73 7d 0d | 0a 24 4a 6f 75 72 6e 61 | burns}.|.$Journa|
|00002100| 6c 7b 4e 20 45 6e 67 6c | 20 4a 20 4d 65 64 7d 0d |l{N Engl| J Med}.|
|00002110| 0a 24 56 6f 6c 75 6d 65 | 7b 33 31 37 7d 0d 0a 24 |.$Volume|{317}..$|
|00002120| 50 61 67 65 7b 34 30 33 | 2d 34 30 38 7d 0d 0a 24 |Page{403|-408}..$|
|00002130| 44 61 74 65 7b 41 75 67 | 20 31 33 2c 20 31 39 38 |Date{Aug| 13, 198|
|00002140| 37 7d 0d 0a 24 59 42 56 | 6f 6c 7b 31 39 38 39 20 |7}..$YBV|ol{1989 |
|00002150| 59 65 61 72 20 42 6f 6f | 6b 20 6f 66 20 50 6c 61 |Year Boo|k of Pla|
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|00002180| 74 69 63 20 53 75 72 67 | 65 72 79 7d 0d 0a 24 43 |tic Surg|ery}..$C|
|00002190| 68 61 70 74 65 72 7b 33 | 2d 32 38 7d 0d 0a 24 59 |hapter{3|-28}..$Y|
|000021a0| 42 45 64 69 74 6f 72 7b | 44 72 73 2e 20 4d 69 6c |BEditor{|Drs. Mil|
|000021b0| 6c 65 72 2c 20 42 65 6e | 6e 65 74 74 2c 20 48 61 |ler, Ben|nett, Ha|
|000021c0| 79 6e 65 73 2c 20 48 6f | 65 68 6e 2c 20 4d 63 4b |ynes, Ho|ehn, McK|
|000021d0| 69 6e 6e 65 79 2c 20 61 | 6e 64 20 57 68 69 74 61 |inney, a|nd Whita|
|000021e0| 6b 65 72 7d 0d 0a 24 54 | 61 62 6c 65 7b 7d 0d 0a |ker}..$T|able{}..|
|000021f0| 24 43 6f 6d 6d 65 6e 74 | 61 74 6f 72 7b 42 2e 57 |$Comment|ator{B.W|
|00002200| 2e 20 48 61 79 6e 65 73 | 2c 20 4a 72 2e 2c 20 4d |. Haynes|, Jr., M|
|00002210| 2e 44 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |.D.}....|Copyrigh|
|00002220| 74 20 28 63 29 20 59 65 | 61 72 20 42 6f 6f 6b 20 |t (c) Ye|ar Book |
|00002230| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|00002240| 72 73 2c 20 49 6e 63 2e | 2c 20 31 39 38 39 0d 0a |rs, Inc.|, 1989..|
|00002250| 0d 0a 31 39 38 39 20 59 | 65 61 72 20 42 6f 6f 6b |..1989 Y|ear Book|
|00002260| 20 6f 66 20 50 6c 61 73 | 74 69 63 2c 20 52 65 63 | of Plas|tic, Rec|
|00002270| 6f 6e 73 74 72 75 63 74 | 69 76 65 2c 20 61 6e 64 |onstruct|ive, and|
|00002280| 20 41 65 73 74 68 65 74 | 69 63 20 53 75 72 67 65 | Aesthet|ic Surge|
|00002290| 72 79 20 28 52 29 0d 0a | 0d 0a 43 68 61 70 74 65 |ry (R)..|..Chapte|
|000022a0| 72 20 33 2d 2d 54 72 61 | 75 6d 61 0d 0a 0d 0a 42 |r 3--Tra|uma....B|
|000022b0| 75 72 6e 73 0d 0a 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |urns....|--------|
|000022c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000022d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000022e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000022f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002300| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 45 66 66 65 63 74 |--------|..Effect|
|00002310| 20 6f 66 20 53 65 76 65 | 72 65 20 42 75 72 6e 20 | of Seve|re Burn |
|00002320| 49 6e 6a 75 72 79 20 6f | 6e 20 53 75 62 73 74 72 |Injury o|n Substr|
|00002330| 61 74 65 20 43 79 63 6c | 69 6e 67 20 62 79 20 47 |ate Cycl|ing by G|
|00002340| 6c 75 63 6f 73 65 20 61 | 6e 64 20 46 61 74 74 79 |lucose a|nd Fatty|
|00002350| 20 41 63 69 64 73 0d 0a | 0d 0a 57 6f 6c 66 65 20 | Acids..|..Wolfe |
|00002360| 52 52 2c 20 48 65 72 6e | 64 6f 6e 20 44 4e 2c 20 |RR, Hern|don DN, |
|00002370| 4a 61 68 6f 6f 72 20 46 | 2c 20 4d 69 79 6f 73 68 |Jahoor F|, Miyosh|
|00002380| 69 20 48 2c 20 57 6f 6c | 66 65 20 4d 0d 0a 28 55 |i H, Wol|fe M..(U|
|00002390| 6e 69 76 20 6f 66 20 54 | 65 78 61 73 2c 20 53 68 |niv of T|exas, Sh|
|000023a0| 72 69 6e 65 72 73 20 42 | 75 72 6e 73 20 49 6e 73 |riners B|urns Ins|
|000023b0| 74 2c 20 47 61 6c 76 65 | 73 74 6f 6e 2c 20 54 65 |t, Galve|ston, Te|
|000023c0| 78 29 0d 0a 4e 20 45 6e | 67 6c 20 4a 20 4d 65 64 |x)..N En|gl J Med|
|000023d0| 20 33 31 37 3a 34 30 33 | 2d 34 30 38 2c 20 41 75 | 317:403|-408, Au|
|000023e0| 67 20 31 33 2c 20 31 39 | 38 37 0d 0a 2d 2d 2d 2d |g 13, 19|87..----|
|000023f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002400| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002410| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002420| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002430| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00002440| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|....    |
|00002450| 20 49 6e 63 72 65 61 73 | 65 73 20 69 6e 20 6d 65 | Increas|es in me|
|00002460| 74 61 62 6f 6c 69 63 20 | 72 61 74 65 20 61 6e 64 |tabolic |rate and|
|00002470| 20 63 6f 72 65 20 74 65 | 6d 70 65 72 61 74 75 72 | core te|mperatur|
|00002480| 65 20 61 72 65 20 63 6f | 6d 6d 6f 6e 20 72 65 73 |e are co|mmon res|
|00002490| 70 6f 6e 73 65 73 20 74 | 6f 0d 0a 73 65 76 65 72 |ponses t|o..sever|
|000024a0| 65 20 69 6e 6a 75 72 79 | 2e 20 20 54 68 65 20 68 |e injury|.  The h|
|000024b0| 79 70 6f 74 68 65 73 69 | 73 20 74 68 61 74 20 74 |ypothesi|s that t|
|000024c0| 68 65 73 65 20 72 65 73 | 70 6f 6e 73 65 73 20 61 |hese res|ponses a|
|000024d0| 72 65 20 74 68 65 20 72 | 65 73 75 6c 74 20 6f 66 |re the r|esult of|
|000024e0| 20 69 6e 63 72 65 61 73 | 65 73 0d 0a 69 6e 20 73 | increas|es..in s|
|000024f0| 75 62 73 74 72 61 74 65 | 20 63 79 63 6c 69 6e 67 |ubstrate| cycling|
|00002500| 20 77 61 73 20 69 6e 76 | 65 73 74 69 67 61 74 65 | was inv|estigate|
|00002510| 64 2e 20 20 54 68 65 20 | 65 78 69 73 74 65 6e 63 |d.  The |existenc|
|00002520| 65 20 6f 66 20 73 75 62 | 73 74 72 61 74 65 20 63 |e of sub|strate c|
|00002530| 79 63 6c 65 73 20 77 61 | 73 0d 0a 70 72 6f 70 6f |ycles wa|s..propo|
|00002540| 73 65 64 20 61 62 6f 75 | 74 20 32 30 20 79 65 61 |sed abou|t 20 yea|
|00002550| 72 73 20 61 67 6f 2c 20 | 70 72 69 6d 61 72 69 6c |rs ago, |primaril|
|00002560| 79 20 6f 6e 20 74 68 65 | 20 62 61 73 69 73 20 6f |y on the| basis o|
|00002570| 66 20 74 68 65 6f 72 65 | 74 69 63 61 6c 0d 0a 63 |f theore|tical..c|
|00002580| 6f 6e 73 69 64 65 72 61 | 74 69 6f 6e 73 20 61 6e |onsidera|tions an|
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|000025b0| 2e 20 20 41 20 73 75 62 | 73 74 72 61 74 65 20 63 |.  A sub|strate c|
|000025c0| 79 63 6c 65 20 6d 61 79 | 20 6f 63 63 75 72 0d 0a |ycle may| occur..|
|000025d0| 77 68 65 6e 20 6f 70 70 | 6f 73 69 6e 67 20 6e 6f |when opp|osing no|
|000025e0| 6e 65 71 75 69 6c 69 62 | 72 69 75 6d 20 72 65 61 |nequilib|rium rea|
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|00002600| 20 62 79 20 64 69 66 66 | 65 72 65 6e 74 20 65 6e | by diff|erent en|
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|00002620| 74 69 6e 67 20 73 69 6d | 75 6c 74 61 6e 65 6f 75 |ting sim|ultaneou|
|00002630| 73 6c 79 2e 0d 0a 20 20 | 20 20 20 54 68 65 72 65 |sly...  |   There|
|00002640| 20 77 65 72 65 20 31 38 | 20 6e 6f 72 6d 61 6c 20 | were 18| normal |
|00002650| 76 6f 6c 75 6e 74 65 65 | 72 73 2c 20 69 6e 63 6c |voluntee|rs, incl|
|00002660| 75 64 69 6e 67 20 31 30 | 20 61 64 75 6c 74 73 20 |uding 10| adults |
|00002670| 61 67 65 64 20 32 31 2d | 33 35 20 79 65 61 72 73 |aged 21-|35 years|
|00002680| 20 61 6e 64 20 38 0d 0a | 63 68 69 6c 64 72 65 6e | and 8..|children|
|00002690| 20 61 67 65 64 20 35 2d | 31 35 20 79 65 61 72 73 | aged 5-|15 years|
|000026a0| 2c 20 61 6e 64 20 31 38 | 20 70 61 74 69 65 6e 74 |, and 18| patient|
|000026b0| 73 20 77 69 74 68 20 73 | 65 76 65 72 65 20 62 75 |s with s|evere bu|
|000026c0| 72 6e 73 2c 20 69 6e 63 | 6c 75 64 69 6e 67 20 38 |rns, inc|luding 8|
|000026d0| 20 61 64 75 6c 74 73 0d | 0a 77 69 74 68 20 61 20 | adults.|.with a |
|000026e0| 6d 65 61 6e 20 61 67 65 | 20 6f 66 20 32 37 20 79 |mean age| of 27 y|
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|00002710| 20 61 67 65 20 6f 66 20 | 38 20 79 65 61 72 73 2c | age of |8 years,|
|00002720| 20 77 68 6f 20 77 65 72 | 65 0d 0a 69 6e 20 61 20 | who wer|e..in a |
|00002730| 68 79 70 65 72 6d 65 74 | 61 62 6f 6c 69 63 20 73 |hypermet|abolic s|
|00002740| 74 61 74 65 2e 20 20 53 | 74 61 62 6c 65 2d 69 73 |tate.  S|table-is|
|00002750| 6f 74 6f 70 65 20 74 72 | 61 63 65 72 73 20 77 65 |otope tr|acers we|
|00002760| 72 65 20 75 73 65 64 20 | 74 6f 20 71 75 61 6e 74 |re used |to quant|
|00002770| 69 66 79 0d 0a 73 75 62 | 73 74 72 61 74 65 20 63 |ify..sub|strate c|
|00002780| 79 63 6c 69 6e 67 20 69 | 6e 20 74 68 65 20 70 61 |ycling i|n the pa|
|00002790| 74 68 77 61 79 73 20 6f | 66 20 67 6c 79 63 6f 6c |thways o|f glycol|
|000027a0| 79 73 69 73 20 61 6e 64 | 20 67 6c 75 63 6f 6e 65 |ysis and| glucone|
|000027b0| 6f 67 65 6e 65 73 69 73 | 20 61 6e 64 20 6f 66 20 |ogenesis| and of |
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|00002820| 20 62 75 72 6e 20 70 61 | 74 69 65 6e 74 73 2c 20 | burn pa|tients, |
|00002830| 74 6f 74 61 6c 20 72 61 | 74 65 73 20 6f 66 20 74 |total ra|tes of t|
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|00002ca0| 6e 63 65 70 74 20 69 73 | 20 63 6f 72 72 65 63 74 |ncept is| correct|
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|00002cf0| 20 61 70 70 72 6f 61 63 | 68 20 6f 66 20 73 69 67 | approac|h of sig|
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|00002d20| 20 70 61 74 69 65 6e 74 | 2e 2d 2d 42 2e 57 2e 0d | patient|.--B.W..|
|00002d30| 0a 48 61 79 6e 65 73 2c | 20 4a 72 2e 2c 20 4d 2e |.Haynes,| Jr., M.|
|00002d40| 44 2e 0d 0a 24 55 6e 69 | 71 75 65 5f 49 44 7b 59 |D...$Uni|que_ID{Y|
|00002d50| 52 42 30 38 37 33 38 7d | 0d 0a 24 54 69 74 6c 65 |RB08738}|..$Title|
|00002d60| 7b 42 75 72 6e 20 57 6f | 75 6e 64 73 20 52 65 73 |{Burn Wo|unds Res|
|00002d70| 75 72 66 61 63 65 64 20 | 62 79 20 43 75 6c 74 75 |urfaced |by Cultu|
|00002d80| 72 65 64 20 45 70 69 64 | 65 72 6d 61 6c 20 41 75 |red Epid|ermal Au|
|00002d90| 74 6f 67 72 61 66 74 73 | 20 53 68 6f 77 20 41 62 |tografts| Show Ab|
|00002da0| 6e 6f 72 6d 61 6c 20 52 | 65 63 6f 6e 73 74 69 74 |normal R|econstit|
|00002db0| 75 74 69 6f 6e 20 6f 66 | 20 41 6e 63 68 6f 72 69 |ution of| Anchori|
|00002dc0| 6e 67 20 46 69 62 72 69 | 6c 73 7d 0d 0a 24 41 75 |ng Fibri|ls}..$Au|
|00002dd0| 74 68 6f 72 7b 0d 0a 57 | 6f 6f 64 6c 65 79 2c 20 |thor{..W|oodley, |
|00002de0| 44 54 0d 0a 50 65 74 65 | 72 73 6f 6e 2c 20 48 44 |DT..Pete|rson, HD|
|00002df0| 0d 0a 48 65 72 7a 6f 67 | 2c 20 53 52 0d 0a 53 74 |..Herzog|, SR..St|
|00002e00| 72 69 63 6b 6c 69 6e 2c | 20 47 50 0d 0a 42 75 72 |ricklin,| GP..Bur|
|00002e10| 67 65 73 6f 6e 2c 20 52 | 45 0d 0a 42 72 69 67 67 |geson, R|E..Brigg|
|00002e20| 61 6d 61 6e 2c 20 52 41 | 0d 0a 43 72 6f 6e 63 65 |aman, RA|..Cronce|
|00002e30| 2c 20 44 4a 0d 0a 4f 27 | 4b 65 65 66 65 2c 20 45 |, DJ..O'|Keefe, E|
|00002e40| 4a 7d 0d 0a 24 41 66 66 | 69 6c 69 61 74 69 6f 6e |J}..$Aff|iliation|
|00002e50| 7b 55 6e 69 76 20 6f 66 | 20 4e 6f 72 74 68 20 43 |{Univ of| North C|
|00002e60| 61 72 6f 6c 69 6e 61 20 | 61 74 20 43 68 61 70 65 |arolina |at Chape|
|00002e70| 6c 20 48 69 6c 6c 3b 20 | 55 6e 69 76 20 6f 66 20 |l Hill; |Univ of |
|00002e80| 54 65 6e 6e 65 73 73 65 | 65 2c 20 4d 65 6d 70 68 |Tennesse|e, Memph|
|00002e90| 69 73 3b 20 53 68 72 69 | 6e 65 72 27 73 20 48 6f |is; Shri|ner's Ho|
|00002ea0| 73 70 20 66 6f 72 20 43 | 72 69 70 70 6c 65 64 20 |sp for C|rippled |
|00002eb0| 43 68 69 6c 64 72 65 6e | 2c 20 50 6f 72 74 6c 61 |Children|, Portla|
|00002ec0| 6e 64 2c 20 4f 72 65 7d | 0d 0a 24 53 75 62 6a 65 |nd, Ore}|..$Subje|
|00002ed0| 63 74 7b 42 75 72 6e 2c | 20 62 75 72 6e 73 20 72 |ct{Burn,| burns r|
|00002ee0| 65 73 75 72 66 61 63 65 | 64 20 77 69 74 68 20 65 |esurface|d with e|
|00002ef0| 70 69 64 65 72 6d 61 6c | 20 61 75 74 6f 67 72 61 |pidermal| autogra|
|00002f00| 66 74 73 2c 20 61 6e 64 | 20 66 69 62 72 69 6c 73 |fts, and| fibrils|
|00002f10| 3b 0d 0a 45 70 69 64 65 | 72 6d 61 6c 20 72 65 73 |;..Epide|rmal res|
|00002f20| 75 72 66 61 63 69 6e 67 | 2c 20 61 6e 64 20 66 69 |urfacing|, and fi|
|00002f30| 62 72 69 6c 73 3b 0d 0a | 47 72 61 66 74 20 65 70 |brils;..|Graft ep|
|00002f40| 69 64 65 72 6d 61 6c 20 | 61 75 74 6f 67 72 61 66 |idermal |autograf|
|00002f50| 74 2c 20 63 75 6c 74 75 | 72 65 64 2c 20 66 6f 72 |t, cultu|red, for|
|00002f60| 20 62 75 72 6e 20 72 65 | 73 75 72 66 61 63 69 6e | burn re|surfacin|
|00002f70| 67 2c 20 61 6e 64 20 66 | 69 62 72 69 6c 73 7d 0d |g, and f|ibrils}.|
|00002f80| 0a 24 4a 6f 75 72 6e 61 | 6c 7b 4a 41 4d 41 7d 0d |.$Journa|l{JAMA}.|
|00002f90| 0a 24 56 6f 6c 75 6d 65 | 7b 32 35 39 7d 0d 0a 24 |.$Volume|{259}..$|
|00002fa0| 50 61 67 65 7b 32 35 36 | 36 2d 32 35 37 31 7d 0d |Page{256|6-2571}.|
|00002fb0| 0a 24 44 61 74 65 7b 4d | 61 79 20 36 2c 20 31 39 |.$Date{M|ay 6, 19|
|00002fc0| 38 38 7d 0d 0a 24 59 42 | 56 6f 6c 7b 31 39 38 39 |88}..$YB|Vol{1989|
|00002fd0| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 50 6c | Year Bo|ok of Pl|
|00002fe0| 61 73 74 69 63 2c 20 52 | 65 63 6f 6e 73 74 72 75 |astic, R|econstru|
|00002ff0| 63 74 69 76 65 2c 20 61 | 6e 64 20 41 65 73 74 68 |ctive, a|nd Aesth|
|00003000| 65 74 69 63 20 53 75 72 | 67 65 72 79 7d 0d 0a 24 |etic Sur|gery}..$|
|00003010| 43 68 61 70 74 65 72 7b | 33 2d 33 32 7d 0d 0a 24 |Chapter{|3-32}..$|
|00003020| 59 42 45 64 69 74 6f 72 | 7b 44 72 73 2e 20 4d 69 |YBEditor|{Drs. Mi|
|00003030| 6c 6c 65 72 2c 20 42 65 | 6e 6e 65 74 74 2c 20 48 |ller, Be|nnett, H|
|00003040| 61 79 6e 65 73 2c 20 48 | 6f 65 68 6e 2c 20 4d 63 |aynes, H|oehn, Mc|
|00003050| 4b 69 6e 6e 65 79 2c 20 | 61 6e 64 20 57 68 69 74 |Kinney, |and Whit|
|00003060| 61 6b 65 72 7d 0d 0a 24 | 54 61 62 6c 65 7b 7d 0d |aker}..$|Table{}.|
|00003070| 0a 24 43 6f 6d 6d 65 6e | 74 61 74 6f 72 7b 42 2e |.$Commen|tator{B.|
|00003080| 57 2e 20 48 61 79 6e 65 | 73 2c 20 4a 72 2e 2c 20 |W. Hayne|s, Jr., |
|00003090| 4d 2e 44 2e 7d 0d 0a 0d | 0a 43 6f 70 79 72 69 67 |M.D.}...|.Copyrig|
|000030a0| 68 74 20 28 63 29 20 59 | 65 61 72 20 42 6f 6f 6b |ht (c) Y|ear Book|
|000030b0| 20 4d 65 64 69 63 61 6c | 20 50 75 62 6c 69 73 68 | Medical| Publish|
|000030c0| 65 72 73 2c 20 49 6e 63 | 2e 2c 20 31 39 38 39 0d |ers, Inc|., 1989.|
|000030d0| 0a 0d 0a 31 39 38 39 20 | 59 65 61 72 20 42 6f 6f |...1989 |Year Boo|
|000030e0| 6b 20 6f 66 20 50 6c 61 | 73 74 69 63 2c 20 52 65 |k of Pla|stic, Re|
|000030f0| 63 6f 6e 73 74 72 75 63 | 74 69 76 65 2c 20 61 6e |construc|tive, an|
|00003100| 64 20 41 65 73 74 68 65 | 74 69 63 20 53 75 72 67 |d Aesthe|tic Surg|
|00003110| 65 72 79 20 28 52 29 0d | 0a 0d 0a 43 68 61 70 74 |ery (R).|...Chapt|
|00003120| 65 72 20 33 2d 2d 54 72 | 61 75 6d 61 0d 0a 0d 0a |er 3--Tr|auma....|
|00003130| 42 75 72 6e 73 0d 0a 0d | 0a 2d 2d 2d 2d 2d 2d 2d |Burns...|.-------|
|00003140| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003150| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003160| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003170| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003180| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 42 75 72 6e 20 |--------|-..Burn |
|00003190| 57 6f 75 6e 64 73 20 52 | 65 73 75 72 66 61 63 65 |Wounds R|esurface|
|000031a0| 64 20 62 79 20 43 75 6c | 74 75 72 65 64 20 45 70 |d by Cul|tured Ep|
|000031b0| 69 64 65 72 6d 61 6c 20 | 41 75 74 6f 67 72 61 66 |idermal |Autograf|
|000031c0| 74 73 20 53 68 6f 77 20 | 41 62 6e 6f 72 6d 61 6c |ts Show |Abnormal|
|000031d0| 0d 0a 52 65 63 6f 6e 73 | 74 69 74 75 74 69 6f 6e |..Recons|titution|
|000031e0| 20 6f 66 20 41 6e 63 68 | 6f 72 69 6e 67 20 46 69 | of Anch|oring Fi|
|000031f0| 62 72 69 6c 73 0d 0a 0d | 0a 57 6f 6f 64 6c 65 79 |brils...|.Woodley|
|00003200| 20 44 54 2c 20 50 65 74 | 65 72 73 6f 6e 20 48 44 | DT, Pet|erson HD|
|00003210| 2c 20 48 65 72 7a 6f 67 | 20 53 52 2c 20 53 74 72 |, Herzog| SR, Str|
|00003220| 69 63 6b 6c 69 6e 20 47 | 50 2c 20 42 75 72 67 65 |icklin G|P, Burge|
|00003230| 73 6f 6e 20 52 45 2c 20 | 42 72 69 67 67 61 6d 61 |son RE, |Briggama|
|00003240| 6e 20 52 41 2c 0d 0a 43 | 72 6f 6e 63 65 20 44 4a |n RA,..C|ronce DJ|
|00003250| 2c 20 4f 27 4b 65 65 66 | 65 20 45 4a 0d 0a 28 55 |, O'Keef|e EJ..(U|
|00003260| 6e 69 76 20 6f 66 20 4e | 6f 72 74 68 20 43 61 72 |niv of N|orth Car|
|00003270| 6f 6c 69 6e 61 20 61 74 | 20 43 68 61 70 65 6c 20 |olina at| Chapel |
|00003280| 48 69 6c 6c 3b 20 55 6e | 69 76 20 6f 66 20 54 65 |Hill; Un|iv of Te|
|00003290| 6e 6e 65 73 73 65 65 2c | 20 4d 65 6d 70 68 69 73 |nnessee,| Memphis|
|000032a0| 3b 20 53 68 72 69 6e 65 | 72 27 73 0d 0a 48 6f 73 |; Shrine|r's..Hos|
|000032b0| 70 20 66 6f 72 20 43 72 | 69 70 70 6c 65 64 20 43 |p for Cr|ippled C|
|000032c0| 68 69 6c 64 72 65 6e 2c | 20 50 6f 72 74 6c 61 6e |hildren,| Portlan|
|000032d0| 64 2c 20 4f 72 65 29 0d | 0a 4a 41 4d 41 20 32 35 |d, Ore).|.JAMA 25|
|000032e0| 39 3a 32 35 36 36 2d 32 | 35 37 31 2c 20 4d 61 79 |9:2566-2|571, May|
|000032f0| 20 36 2c 20 31 39 38 38 | 0d 0a 2d 2d 2d 2d 2d 2d | 6, 1988|..------|
|00003300| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003310| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003320| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003330| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003340| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 0d 0a 41 62 |--------|--....Ab|
|00003350| 73 74 72 61 63 74 0d 0a | 0d 0a 20 20 20 20 20 46 |stract..|..     F|
|00003360| 6f 75 72 20 62 75 72 6e | 20 70 61 74 69 65 6e 74 |our burn| patient|
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|00003380| 64 73 20 63 6f 76 65 72 | 65 64 20 62 79 20 63 75 |ds cover|ed by cu|
|00003390| 6c 74 75 72 65 64 20 6b | 65 72 61 74 69 6e 6f 63 |ltured k|eratinoc|
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|000033b0| 62 75 74 20 65 78 68 69 | 62 69 74 65 64 20 73 6b |but exhi|bited sk|
|000033c0| 69 6e 20 66 72 61 67 69 | 6c 69 74 79 20 66 6f 72 |in fragi|lity for|
|000033d0| 20 75 70 20 74 6f 20 37 | 20 6d 6f 6e 74 68 73 20 | up to 7| months |
|000033e0| 61 66 74 65 72 20 67 72 | 61 66 74 69 6e 67 20 6f |after gr|afting o|
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|00003550| 6e 20 61 6c 6c 20 70 61 | 74 69 65 6e 74 73 2c 20 |n all pa|tients, |
|00003560| 74 68 65 20 72 65 63 6f | 6e 73 74 69 74 75 74 65 |the reco|nstitute|
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|00003580| 61 6e 65 20 7a 6f 6e 65 | 20 62 65 6e 65 61 74 68 |ane zone| beneath|
|00003590| 20 74 68 65 0d 0a 61 75 | 74 6f 67 72 61 66 74 73 | the..au|tografts|
|000035a0| 20 77 61 73 20 69 6e 63 | 6f 6d 70 6c 65 74 65 2c | was inc|omplete,|
|000035b0| 20 6c 61 63 6b 69 6e 67 | 20 74 79 70 65 20 49 56 | lacking| type IV|
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|00005110| 20 63 61 6e 20 62 65 20 | 63 61 75 73 65 64 20 62 | can be |caused b|
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|00005140| 65 72 67 79 20 28 61 6c | 74 68 6f 75 67 68 20 74 |ergy (al|though t|
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|000051c0| 2c 0d 0a 6c 69 6b 65 20 | 6d 61 6e 79 20 6f 66 20 |,..like |many of |
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|00005200| 63 61 6c 20 6f 66 20 74 | 68 65 20 61 75 74 68 6f |cal of t|he autho|
|00005210| 72 73 27 0d 0a 70 72 6f | 76 6f 63 61 74 69 76 65 |rs'..pro|vocative|
|00005220| 20 63 6f 6e 63 6c 75 73 | 69 6f 6e 2e 20 20 48 6f | conclus|ion.  Ho|
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|00005260| 0a 64 65 66 69 6e 69 74 | 69 76 65 6c 79 20 62 79 |.definit|ively by|
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|000052a0| 20 61 20 67 6f 6f 64 20 | 6f 6e 65 3b 20 77 65 0d | a good |one; we.|
|000052b0| 0a 6c 6f 6f 6b 20 66 6f | 72 77 61 72 64 20 74 6f |.look fo|rward to|
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|000052e0| 53 2e 50 2e 20 50 65 74 | 65 72 73 2c 20 4d 2e 44 |S.P. Pet|ers, M.D|
|000052f0| 2e 2c 20 50 68 2e 44 2e | 0d 0a 24 55 6e 69 71 75 |., Ph.D.|..$Uniqu|
|00005300| 65 5f 49 44 7b 59 52 42 | 30 38 37 35 31 7d 0d 0a |e_ID{YRB|08751}..|
|00005310| 24 54 69 74 6c 65 7b 44 | 69 66 66 65 72 65 6e 63 |$Title{D|ifferenc|
|00005320| 65 73 20 69 6e 20 48 6f | 73 70 69 74 61 6c 20 41 |es in Ho|spital A|
|00005330| 73 74 68 6d 61 20 4d 61 | 6e 61 67 65 6d 65 6e 74 |sthma Ma|nagement|
|00005340| 7d 0d 0a 24 41 75 74 68 | 6f 72 7b 0d 0a 42 75 63 |}..$Auth|or{..Buc|
|00005350| 6b 6e 61 6c 6c 2c 20 43 | 45 0d 0a 52 6f 62 65 72 |knall, C|E..Rober|
|00005360| 74 73 6f 6e 2c 20 43 0d | 0a 4d 6f 72 61 6e 2c 20 |tson, C.|.Moran, |
|00005370| 46 0d 0a 53 74 65 76 65 | 6e 73 6f 6e 2c 20 52 44 |F..Steve|nson, RD|
|00005380| 7d 0d 0a 24 41 66 66 69 | 6c 69 61 74 69 6f 6e 7b |}..$Affi|liation{|
|00005390| 47 6c 61 73 67 6f 77 20 | 52 6f 79 61 6c 20 49 6e |Glasgow |Royal In|
|000053a0| 66 69 72 6d 61 72 79 3b | 20 53 74 72 61 74 68 63 |firmary;| Strathc|
|000053b0| 6c 79 64 65 20 55 6e 69 | 76 2c 20 47 6c 61 73 67 |lyde Uni|v, Glasg|
|000053c0| 6f 77 7d 0d 0a 24 53 75 | 62 6a 65 63 74 7b 41 73 |ow}..$Su|bject{As|
|000053d0| 74 68 6d 61 2c 20 68 6f | 73 70 69 74 61 6c 20 6d |thma, ho|spital m|
|000053e0| 61 6e 61 67 65 6d 65 6e | 74 2c 20 64 69 66 66 65 |anagemen|t, diffe|
|000053f0| 72 65 6e 63 65 73 20 69 | 6e 7d 0d 0a 24 4a 6f 75 |rences i|n}..$Jou|
|00005400| 72 6e 61 6c 7b 4c 61 6e | 63 65 74 7d 0d 0a 24 56 |rnal{Lan|cet}..$V|
|00005410| 6f 6c 75 6d 65 7b 31 7d | 0d 0a 24 50 61 67 65 7b |olume{1}|..$Page{|
|00005420| 37 34 38 2d 37 35 30 7d | 0d 0a 24 44 61 74 65 7b |748-750}|..$Date{|
|00005430| 41 70 72 20 32 2c 20 31 | 39 38 38 7d 0d 0a 24 59 |Apr 2, 1|988}..$Y|
|00005440| 42 56 6f 6c 7b 31 39 38 | 39 20 59 65 61 72 20 42 |BVol{198|9 Year B|
|00005450| 6f 6f 6b 20 6f 66 20 50 | 75 6c 6d 6f 6e 61 72 79 |ook of P|ulmonary|
|00005460| 20 44 69 73 65 61 73 65 | 7d 0d 0a 24 43 68 61 70 | Disease|}..$Chap|
|00005470| 74 65 72 7b 32 2d 32 36 | 7d 0d 0a 24 59 42 45 64 |ter{2-26|}..$YBEd|
|00005480| 69 74 6f 72 7b 44 72 73 | 2e 20 47 72 65 65 6e 2c |itor{Drs|. Green,|
|00005490| 20 42 61 6c 6c 2c 20 4d | 69 63 68 61 65 6c 2c 20 | Ball, M|ichael, |
|000054a0| 50 65 74 65 72 73 2c 20 | 54 65 72 72 79 2c 20 54 |Peters, |Terry, T|
|000054b0| 6f 63 6b 6d 61 6e 2c 20 | 61 6e 64 20 57 69 73 65 |ockman, |and Wise|
|000054c0| 7d 0d 0a 24 54 61 62 6c | 65 7b 54 61 62 6c 65 20 |}..$Tabl|e{Table |
|000054d0| 4f 6d 69 74 74 65 64 7d | 0d 0a 24 43 6f 6d 6d 65 |Omitted}|..$Comme|
|000054e0| 6e 74 61 74 6f 72 7b 53 | 2e 50 2e 20 50 65 74 65 |ntator{S|.P. Pete|
|000054f0| 72 73 2c 20 4d 2e 44 2e | 2c 20 50 68 2e 44 2e 7d |rs, M.D.|, Ph.D.}|
|00005500| 0d 0a 0d 0a 43 6f 70 79 | 72 69 67 68 74 20 28 63 |....Copy|right (c|
|00005510| 29 20 59 65 61 72 20 42 | 6f 6f 6b 20 4d 65 64 69 |) Year B|ook Medi|
|00005520| 63 61 6c 20 50 75 62 6c | 69 73 68 65 72 73 2c 20 |cal Publ|ishers, |
|00005530| 49 6e 63 2e 2c 20 31 39 | 38 39 0d 0a 0d 0a 31 39 |Inc., 19|89....19|
|00005540| 38 39 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |89 Year |Book of |
|00005550| 50 75 6c 6d 6f 6e 61 72 | 79 20 44 69 73 65 61 73 |Pulmonar|y Diseas|
|00005560| 65 20 28 52 29 0d 0a 0d | 0a 43 68 61 70 74 65 72 |e (R)...|.Chapter|
|00005570| 20 32 2d 2d 41 73 74 68 | 6d 61 20 61 6e 64 20 53 | 2--Asth|ma and S|
|00005580| 65 6c 65 63 74 65 64 20 | 49 6d 6d 75 6e 6f 6c 6f |elected |Immunolo|
|00005590| 67 69 63 61 6c 6c 79 20 | 4d 65 64 69 61 74 65 64 |gically |Mediated|
|000055a0| 20 4c 75 6e 67 20 44 69 | 73 65 61 73 65 73 0d 0a | Lung Di|seases..|
|000055b0| 0d 0a 54 68 65 72 61 70 | 79 0d 0a 0d 0a 2d 2d 2d |..Therap|y....---|
|000055c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000055d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000055e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000055f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005600| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 44 |--------|-----..D|
|00005610| 69 66 66 65 72 65 6e 63 | 65 73 20 69 6e 20 48 6f |ifferenc|es in Ho|
|00005620| 73 70 69 74 61 6c 20 41 | 73 74 68 6d 61 20 4d 61 |spital A|sthma Ma|
|00005630| 6e 61 67 65 6d 65 6e 74 | 0d 0a 0d 0a 42 75 63 6b |nagement|....Buck|
|00005640| 6e 61 6c 6c 20 43 45 2c | 20 52 6f 62 65 72 74 73 |nall CE,| Roberts|
|00005650| 6f 6e 20 43 2c 20 4d 6f | 72 61 6e 20 46 2c 20 53 |on C, Mo|ran F, S|
|00005660| 74 65 76 65 6e 73 6f 6e | 20 52 44 0d 0a 28 47 6c |tevenson| RD..(Gl|
|00005670| 61 73 67 6f 77 20 52 6f | 79 61 6c 20 49 6e 66 69 |asgow Ro|yal Infi|
|00005680| 72 6d 61 72 79 3b 20 53 | 74 72 61 74 68 63 6c 79 |rmary; S|trathcly|
|00005690| 64 65 20 55 6e 69 76 2c | 20 47 6c 61 73 67 6f 77 |de Univ,| Glasgow|
|000056a0| 29 0d 0a 4c 61 6e 63 65 | 74 20 31 3a 37 34 38 2d |)..Lance|t 1:748-|
|000056b0| 37 35 30 2c 20 41 70 72 | 20 32 2c 20 31 39 38 38 |750, Apr| 2, 1988|
|000056c0| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|000056d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000056e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000056f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005700| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005710| 2d 2d 0d 0a 0d 0a 41 62 | 73 74 72 61 63 74 0d 0a |--....Ab|stract..|
|00005720| 0d 0a 20 20 20 20 20 41 | 20 73 75 72 76 65 79 20 |..     A| survey |
|00005730| 6f 66 20 61 73 74 68 6d | 61 20 70 61 74 69 65 6e |of asthm|a patien|
|00005740| 74 73 20 74 72 65 61 74 | 65 64 20 64 75 72 69 6e |ts treat|ed durin|
|00005750| 67 20 31 20 79 65 61 72 | 20 61 74 20 74 68 65 20 |g 1 year| at the |
|00005760| 47 6c 61 73 67 6f 77 20 | 52 6f 79 61 6c 0d 0a 49 |Glasgow |Royal..I|
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|00005780| 68 61 74 20 64 69 61 67 | 6e 6f 73 69 73 2c 20 6d |hat diag|nosis, m|
|00005790| 61 6e 61 67 65 6d 65 6e | 74 2c 20 61 6e 64 20 66 |anagemen|t, and f|
|000057a0| 6f 6c 6c 6f 77 2d 75 70 | 20 76 61 72 79 20 63 6f |ollow-up| vary co|
|000057b0| 6e 73 69 64 65 72 61 62 | 6c 79 0d 0a 61 6d 6f 6e |nsiderab|ly..amon|
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|000057f0| 68 61 76 69 6e 67 20 61 | 20 73 70 65 63 69 61 6c |having a| special|
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|00005890| 20 77 69 74 68 6f 75 74 | 20 72 65 73 70 69 72 61 | without| respira|
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|00005910| 78 0d 0a 64 69 73 74 72 | 69 62 75 74 69 6f 6e 2c |x..distr|ibution,|
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|00005940| 67 72 6f 75 70 20 52 20 | 68 61 64 20 73 69 67 6e |group R |had sign|
|00005950| 69 66 69 63 61 6e 74 6c | 79 20 68 69 67 68 65 72 |ificantl|y higher|
|00005960| 0d 0a 72 61 74 65 73 20 | 6f 66 20 74 72 65 61 74 |..rates |of treat|
|00005970| 6d 65 6e 74 20 77 69 74 | 68 20 6f 72 61 6c 20 63 |ment wit|h oral c|
|00005980| 6f 72 74 69 63 6f 73 74 | 65 72 6f 69 64 73 2c 20 |orticost|eroids, |
|00005990| 6d 6f 6e 69 74 6f 72 69 | 6e 67 20 6f 66 20 70 65 |monitori|ng of pe|
|000059a0| 61 6b 20 66 6c 6f 77 20 | 72 61 74 65 73 20 6f 72 |ak flow |rates or|
|000059b0| 0d 0a 73 70 69 72 6f 6d | 65 74 72 79 2c 20 61 6e |..spirom|etry, an|
|000059c0| 64 20 61 70 70 6f 69 6e | 74 6d 65 6e 74 73 20 66 |d appoin|tments f|
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|00005a00| 6f 75 74 63 6f 6d 65 73 | 20 77 65 72 65 20 6d 61 |outcomes| were ma|
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|00005a20| 20 67 72 6f 75 70 20 52 | 20 70 61 74 69 65 6e 74 | group R| patient|
|00005a30| 73 20 28 54 61 62 6c 65 | 20 31 29 2e 20 20 42 65 |s (Table| 1).  Be|
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|00005a50| 67 65 20 61 67 65 20 6f | 66 20 67 72 6f 75 70 20 |ge age o|f group |
|00005a60| 47 20 70 61 74 69 65 6e | 74 73 20 77 61 73 20 73 |G patien|ts was s|
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|00005ad0| 20 49 6d 70 6f 72 74 61 | 6e 74 20 64 69 66 66 65 | Importa|nt diffe|
|00005ae0| 72 65 6e 63 65 73 0d 0a | 72 65 6d 61 69 6e 65 64 |rences..|remained|
|00005af0| 20 73 69 67 6e 69 66 69 | 63 61 6e 74 20 69 6e 20 | signifi|cant in |
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|00005c30| 20 61 73 74 68 6d 61 20 | 74 68 65 72 61 70 79 2c | asthma |therapy,|
|00005c40| 20 6d 6f 72 74 61 6c 69 | 74 79 20 72 61 74 65 73 | mortali|ty rates|
|00005c50| 20 68 61 76 65 20 6e 6f | 74 20 66 61 6c 6c 65 6e | have no|t fallen|
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+--------+-------------------------+-------------------------+--------+--------+